#822: The Random Show — Ketones for Cognition, Tim’s Best Lab Results in 10+ Years, How Kevin Hit 100 Days Sober, Home Defense, Vibe Coding Unleashed, and More
100 Days Alcohol-Free Routine and Sustainable Lifestyle Changes
Kevin Rose recounts reaching 100 days without alcohol and how social support, daily micro-goals, and practical replacements helped maintain sobriety. The conversation emphasizes incremental wins — “not today” thinking — and the measurable health improvements that followed, including normalized liver enzymes and more stable mood. Practical habits such as replacing evening drinks with low-effort hobbies and peer hotlines made a long-term change achievable.
Ketogenic Short-Term Protocols And Intermittent Fasting For Cognitive Health
Tim and Kevin describe a short, intentional ketogenic cycle followed by 16:8 intermittent fasting to reset metabolic markers. They report improved insulin sensitivity, better mood stability, and reduced abdominal fat after weeks of disciplined eating windows and controlled protein intake. They recommend working with clinicians, tracking biomarkers like APOB and oral glucose tolerance tests, and using resistance training to preserve muscle during fasting windows.
Exogenous Ketones, Creatine, And GLP-1 Microdosing For Brain Function
Exogenous ketone supplements such as palatable ketone powders and ketone monoesters are discussed as tools to elevate circulating ketones quickly for cognitive clarity. Kevin notes some experimental, high-cost ketone monoesters behave like a “Bugatti” of ketones, whereas other products are more affordable. Both hosts also highlight creatine for cognitive resilience and the emerging practice of microdosing GLP-1 agonists to blunt glucose spikes, improve fasting glucose, and potentially provide neuroprotective benefits under medical supervision.
Modern Home Defense Tips And Practical Personal Safety
An unsettling anecdote about finding a homeless person hiding in a showing underscores a need to re-evaluate home security. The episode outlines prevention-first strategies: privacy practices (mail handling, property ownership structure), building choice (secured high-rise entry), non-lethal options (bear spray over small-range pepper spray), and realistic training suggestions for any chosen tool. Prevention and red-teaming one’s own exposure are prioritized above dramatic defensive fantasies.
Vibe Coding, AI Disruption, And The Future Of Early-Stage Venture Capital
The guests cover how “vibe coding” and AI tooling dramatically lower barriers to creating apps and websites, accelerating idea-to-prototype timelines and changing seed-stage dynamics. Expect far more creators, cheaper launches, and a tougher signal-to-noise environment for VCs. Original human-generated content, authenticated identity signals, and in-person community experiences are suggested as durable value sources in the age of synthetic media.
Analog Hobbies, Community, And Product Launch Highlights
The episode celebrates low-tech hobbies — nano blocks, board games, and offline meetups — as antidotes to digital overload. Kevin’s new card game Coyote is discussed as a case study in analog virality and retail rollout, showing how tactile social products can cut through algorithmic noise.
Insights
- Set digestible sobriety goals by focusing on ‘not today’ and enlist friends who have done the work.
- Use an oral glucose tolerance test rather than fasting glucose alone to accurately assess metabolic health.
- Combine short-term ketosis with intermittent fasting and resistance training to improve body composition safely.
- Test exogenous ketones cautiously while monitoring GI tolerance and blood ketone levels for cognitive effects.
- Implement privacy-first practices like alternate mailing addresses and entity ownership to reduce stalking risk.
- Favor prevention and simple non-lethal deterrents for home security over high-risk confrontations.
- Learn and experiment with vibe-coding platforms to launch prototypes quickly before seeking venture funding.
FAQ
How did Kevin sustain 100 days without alcohol?
Kevin used peer support, daily micro-goals like 'not today', hotline calls, and alternative activities to replace drinking.
What is the recommended way to measure glucose and insulin response?
An oral glucose tolerance test with serial blood draws provides a clearer picture of spikes and recovery than fasting glucose alone.
Are exogenous ketones and ketone monoesters safe and effective?
Exogenous ketones can raise blood ketones quickly and improve mental clarity for some, but tolerability and long-term safety vary and require medical guidance.
What home defense steps do the hosts recommend after a stranger was found in a closet?
Prioritize prevention: privacy practices, secure mailing, building selection, non-lethal deterrents like bear spray, and realistic training for chosen tools.
How will vibe coding change early-stage venture capital?
Vibe coding lowers the cost and time to launch apps, increasing idea volume, making early filtering harder, and shifting VC focus toward later-stage growth capital.
