TuneInTalks
From The Diary Of A CEO with Steven Bartlett

The Diabetes Doctor: 80% Of Adults Are Heading For Chronic Disease! Keto’s Shocking Effect On Your Brain!

1:32:38
September 8, 2025
The Diary Of A CEO with Steven Bartlett
https://feeds.megaphone.fm/thediaryofaceo

The quiet revolution in how we understand food, fuel, and the brain

When metabolic science stops being academic and becomes intimate, it changes the way people live. Dr. Andrew Kutynik, a research scientist who has spent years with continuous glucose monitors and insulin pumps attached to his body, describes metabolic health not as abstract lab metrics but as lived experience: the swing of energy, the bluntness of mood, the slow accrual of vascular damage. His life story — from childhood obesity to a diagnosis that reframed his priorities — gives the technical findings a human weight. What follows is a consideration of the ideas he’s pushed into the mainstream: that carbohydrate exposure is the most powerful lever for blood glucose; that ketogenic physiology can stabilize cognition and performance; and that small, everyday choices in the grocery aisle can change decades of health.

From childhood photos to clinical instruments

The contrast is cinematic: photographs of a heavy child who "did everything he was told" meet live-readouts of glucose and insulin on a phone screen. Kutynik uses those devices not as gadgets but as instruments of clarity. A continuous glucose monitor reveals what routine medical visits rarely can — the hour-to-hour volatility that erodes concentration and quietly accelerates vascular stiffening. He frames HbA1c, the three-month average of blood sugar, as the engine under the hood: without it functioning, other optimizations are cosmetic. For children with uncontrolled glucose, he warns, neurodevelopmental effects can appear within three years; that urgency recasts diet from preference to intervention.

What a ketogenic diet actually looks like — and why it matters

Popular imagery reduces ketogenic eating to bacon and steak. The reality Kutynik describes is more nuanced: a well-formulated, low-carbohydrate approach emphasizes green leafy vegetables, fiber-rich crucifers, adequate protein, and healthy plant fats like olive oil and avocado. The critical piece is not moralizing foods but tracking their metabolic impact: carbohydrates are the most potent driver of post-meal glucose spikes and insulin surges. For people with metabolic dysfunction, those spikes create a feedback loop that fuels hunger and eventually insulin resistance.

Adaptation, performance, and the surprising flexibility of fuel

For athletes, the prevailing story for a century has been that carbohydrates are essential. Early 20th-century marathon experiments and later muscle-biopsy research reinforced the link between glycogen stores and endurance. But when adaptation time is accounted for — four weeks or more — a different picture emerges. Kutynik’s controlled work shows that once the body shifts into sustained ketosis, fat oxidation during intense exercise can reach levels previously thought impossible, and performance can be preserved.

  • Adaptation matters: short-term trials underestimate long-term physiology.
  • Ketone-fueled athletes can burn unusually high amounts of fat even at high intensities.
  • Practical training protocols should consider dietary phase as part of periodization.

Exogenous ketones: a metabolic shortcut

If diet produces ketones over weeks, exogenous ketone supplements produce them in minutes. The compounds tested in military and clinical research show acute effects on blood glucose, markers of inflammation, and brain network stability. In MRI-based studies, ketone ingestion increased the stability of brain networks while glucose destabilized them; other trials suggest benefits for cognition, mood, and even a slowed trajectory in certain neurodegenerative markers. The distinction is important: exogenous ketones are not a cure, but they are a tool that rapidly changes metabolic context and, in some studies, performance and clinical outcomes.

Labels, palatability, and the engineered food environment

One of the most political parts of Kutynik’s diagnosis is his assessment of the grocery store. Products labeled "keto-friendly" or "zero sugar" are often reformulated with sugar alcohols and refined starches that elicit the very glycemic responses they claim to avoid. Highly processed combinations of fat, salt, and carbohydrate exaggerate reward signals in the brain, promoting overeating and metabolic disturbance — a design problem, not a failure of will. For many people, simply removing liquid calories and packaged confections from routine consumption is a structural change with outsized benefits.

When markers diverge: LDL and cardiovascular context

Perhaps the most counterintuitive finding Kutynik presents is that LDL cholesterol can rise on a low-carbohydrate diet while more sensitive measures of cardiovascular health remain favorable. In a decade-long single-patient study of type 1 diabetes, LDL nearly doubled but advanced cardiovascular assessments showed preserved or improved vascular function, reduced insulin exposure, and dramatically better glycemic control. The implication is that isolated lab values cannot be divorced from context; metabolic control, inflammation, and vascular responsiveness are part of the same story.

Practical threads that tie research to daily life

There is no single prescription for everyone, but several repeatable strategies emerge: monitor meaningful signals (glucose variability, not culinary dogma); reduce high-glycemic and liquid calories; prioritize resistance exercise and adequate protein to preserve lean mass; and respect the biological time needed to adapt to new fuel sources. Kutynik emphasizes self-experimentation: population averages hide individual response variability. Trying a therapeutic carbohydrate restriction under medical guidance reveals whether a person is a responder or not, and that knowledge is more valuable than any generalized headline.

Final thought: the revolution Kutynik describes is not simply a change in diet; it is a shift in how we treat the body’s real-time signals — a new attentiveness to fuel, fluctuation, and function that reframes food as a long-term intervention, not a short-term pleasure. The real measure of success will be cultural: whether societies design food systems and clinical advice that preserve brain development, extend vascular health, and recognize that stabilizing one molecule in the bloodstream can rewrite decades of illness.

Key points

  • Therapeutic carbohydrate restriction can normalize glycemic control in many with diabetes.
  • A well-formulated ketogenic diet emphasizes vegetables, protein, and healthy plant fats.
  • Ketogenic adaptation takes four weeks or more for durable performance benefits.
  • Exogenous ketones rapidly raise blood ketones and can stabilize brain network activity.
  • Continuous glucose monitoring reveals variability that correlates with cognition and mood.
  • Liquid calories and refined, processed foods often drive unexpected glucose spikes.
  • In a 10-year type 1 study, LDL rose but cardiovascular function and glycemic control improved.

Timecodes

00:00 Opening question and research claims
00:00 Personal history: childhood obesity and diagnosis
00:03 Defining metabolism and research focus
00:07 Demonstrating insulin pump and CGM readings
00:13 Explaining the ketogenic diet and its evolution
00:21 Orange consumption glucose demonstration
00:36 Ten-year ketogenic study in type 1 diabetes
00:44 Ketogenic diet, adaptation, and athletic performance
00:52 Exogenous ketones, DARPA research, and cognition
00:01 Practical dietary advice and closing reflections

More from The Diary Of A CEO with Steven Bartlett

The Diary Of A CEO with Steven Bartlett
Fat Burning Expert: The Real Reason You Can’t Lose Weight! PCOS, Menopause & Stubborn Belly Fat
Learn evidence-backed nutrition rules that actually improve muscle and fat outcomes now.
2:06:48
Aug 25, 2025
The Diary Of A CEO with Steven Bartlett
Most Replayed Moment: Alain de Botton - Individualism Is Making Us Miserable!
Discover why modern success breeds loneliness and how to reclaim genuine human connection.
19:13
Aug 22, 2025
The Diary Of A CEO with Steven Bartlett
Mohnish Pabrai (Billionaire Investor): The $100 Investment Hack That's Disappearing Fast! The Fastest Way To Financial Freedom!
Learn the Dando way to start businesses with little risk and big upside.
1:46:49
Aug 21, 2025
The Diary Of A CEO with Steven Bartlett
ChatGPT Brain Rot Debate: The Fastest Way to Get Dementia, Watch This Before Using ChatGPT Again, Especially If Your Kids Use It!
Discover how AI could reshape your brain — and how to protect it.
1:33:41
Aug 18, 2025

You Might Also Like

00:0000:00